Searching for better treatment options for people living with eye disease.

Current & Upcoming Clinical Trials

At Ophthalmic Trials Australia, we are actively involved in clinical research focused on advancing the treatment of anterior eye disease, ocular surface disease, dry eye disease, keratoconus, glaucoma, and ocular pain.

Our clinical trials provide eligible participants with access to emerging therapies and technologies while contributing to the future development of eye care.

Currently Recruiting Studies

Keratoconus Clinical Trial — OPEN NOW

Phase I Keratoconus Study

NCT07388069

Participants: Mild to moderate keratoconus patients aged 18–40 years

A proof-of-concept, randomized, open-label, three-cohort clinical trial investigating the safety and preliminary efficacy of a novel topical ophthalmic intervention designed to prevent progression of keratoconus.

This study is focused on exploring future non-surgical treatment options for progressive keratoconus.

Glaucoma & Ocular Hypertension Study — OPEN NOW

ACTRN12625000766415

A Phase I clinical trial designed to evaluate the safety, tolerability, and preliminary efficacy of investigational ophthalmic solutions in patients diagnosed with:

• Primary Open-Angle Glaucoma (POAG)
• Ocular Hypertension (OHT)

Ocular Surface Pain Study — OPEN NOW

ACTRN12626000137392p

Phase I / Phase II Clinical Trial

A clinical trial investigating the safety and preliminary efficacy of novel topical ophthalmic drops in participants with moderate ocular surface pain.

A Phase 1b Placebo-Controlled Single Safety Dose/Multiple Ascending Dose and
Phase 2a Trial to Evaluate the Maximum Tolerated Dose and Analgesic Effect of
novel topical eye drop on Ocular Pain in Subjects with Moderate to Severe Dry Eye Disease.

Sjögren’s Related Dry Eye Disease Trial — OPEN NOW

NCT07118241

Phase II — 28 Day Study

A prospective randomized crossover study assessing the acute safety and efficacy of investigational product compared with vehicle in participants with Sjögren’s related dry eye disease.

Ocular Graft-Versus-Host Disease (oGVHD) — OPEN NOW

NCT07118254

A Phase II prospective crossover study investigating novel treatment approaches for ocular graft-versus-host disease.

Phase IV Dry Eye Disease Clinical Trial — OPEN NOW

NCT07238699

A post-market Phase IV clinical trial assessing the effectiveness of commercially available dry eye treatments compared with novel ophthalmic formulations.

Completed Clinical Trials

Chronic Ocular Surface Pain (COSP) — COMPLETED

ETX4143-A002

Phase II clinical trial investigating an in-clinic ophthalmic cooling device treatment for chronic ocular surface pain greater than 3 months in duration, with or without dry eye disease.

Dry Eye Disease Clinical Trial — COMPLETED

ST-100-002

A Phase III multi-centre, randomized, double-masked, vehicle-controlled study assessing the safety and efficacy of ST-100 (vezocolmitide) ophthalmic solution in subjects diagnosed with dry eye disease.

Sjögren’s Related Dry Eye Disease One-Day Trial — COMPLETED

A Phase II prospective randomized crossover study assessing the acute safety and efficacy of investigational product compared with vehicle for Sjögren’s related dry eye disease.

Dry Eye Disease with Autoimmune Disease — COMPLETED

ILYX-002-201

A multicentre, randomized, controlled, double-masked Phase II clinical trial assessing the safety and therapeutic effects of ILYX-002 versus vehicle control for dry eye disease in participants with autoimmune disease.

Ocular Graft-Versus-Host Disease (oGVHD) — COMPLETED

rhPRG4-oGVHD-001

A Phase I prospective open-label study assessing the safety and efficacy of investigational therapy for ocular graft-versus-host disease.

Postponed Studies

Ocular Hypertension Cooling Device Study — POSTPONED

NCT06709300

A prospective early-feasibility clinical study evaluating the safety and effectiveness of a topical ophthalmic cooling device in patients with ocular hypertension.

In the OTA Research Pipeline

We are continuing to expand our ophthalmic clinical research program with future studies anticipated in:

• Neurotrophic Keratitis
• Vernal Keratoconjunctivitis (VKC) in paediatric patients
• Moderate to severe inflammatory dry eye disease
• Meibomian gland dysfunction and evaporative dry eye disease
• Platelet lysate therapies for dry eye disease
• Novel ocular surface therapeutics and regenerative therapies

Register Your Interest

If you are interested in participating in a clinical trial, we invite you to register your interest with our team.

Tracey@ot-au.com or scan the QR code at the top of this page.

Please advise which clinical trial or condition you are interested in when contacting us.

Ophthalmic Trials Australia

Searching for better treatment options for people living with eye disease.